Structure of E. coli dihydrofolate reductase (DHFR) in an occluded conformation and in complex with cycloguanil

Structure of E. coli dihydrofolate reductase (DHFR) in an occluded conformation and in complex with cycloguanil Descriptor: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, CITRATE ANION, Dihydrofolate reductase Authors: Berkovich, D.A, Jez, J.M. Deposit date: 2024-08-22 Release date: 2025-02-26 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines. Acs Infect Dis., 11, 2025