Benzopyran derivatives from Melicope pteleifolia

Phytochemical investigation of M. pteleifolia branches and leaves led to the isolation of seven benzopyran derivatives, including five new ones named melicopols A − E (2 − 6). The chemical structures were confirmed by extensive analysis of the 1D, 2D NMR, CD, and HR-QTOF mass spectra. The absolute configuration 1′S of leptol A (1) was firstly confirmed by experimental and calculated ECD data. Their cytotoxic activity on three human cancer cell lines HepG2 (hepatoma), SK-LU-1 (lung), and MCF7 (breast) was also evaluated using SRB assay.