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Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke

Alliance of Genome Resources2026-08-01 收录

脑卒中后基因表达分析

治疗靶点发现

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE55260 数据链接链接失效反馈

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资源简介：

We employed the Affymetrix platform to analyze the whole-gene transcriptome following temporary ligation of the middle cerebral artery in aged and young rats.

应用场景：

布尔网络

治疗靶点发现

The equations of the case study in text format.

DataCite Commons2020-08-30 更新50

Bone morphogenetic protein 8b (bmp8b) in non-alcoholic steatohepatitis (nash), acute hepatic damage and liver regeneration

肝肾疾病分子机制

治疗靶点发现

TGFÃ/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model), acute liver damage (CCl4 model) and by Partial Hepatectomy (PH). Absence of Bmp8b reduce

NIAID Data Ecosystem20

Additional file 11: Table S3. of A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer

结直肠癌分子机制

治疗靶点发现

Raw quantitative-PCR data for each PCR array used in this study. Clinical data associated to CRC samples were indicated in the excel file. (XLSX 412 kb)

Figshare2017-09-30 更新10

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas [RNA-seq]. MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas [RNA-seq]

肿瘤抗原呈递

治疗靶点发现

Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival

NIAID Data Ecosystem30

scRNA-seq of cancer and CD8+ cells during early metastasis identifies targetable subpopulations and immune evasion mechanisms. scRNA-seq of cancer and CD8+ cells during early metastasis identifies targetable subpopulations and immune evasion mechanisms

肿瘤微环境细胞分析

治疗靶点发现

Profiling tumors at single-cell resolution provides an opportunity to understand complexities underpinning lymph-node metastases in head and neck squamous-cell carcinoma. Single-cell RNAseq (scRNAseq)

NIAID Data Ecosystem10

Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke

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