Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis'

Peripheral blood and adipose tissue were collected from eight healthy donors and eight multiple sclerosis (MS) patients. Two of the MS patients were untreated and the rest had previously received disease modifying treatments (DMTs). This study compared the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidonic acid. The role of fatty acids in regulating tissue inflammatory signals was investigated in healthy donors and MS patients by comparing single-cell transcriptomic profiles of blood and adipose tissue samples with in vitro stimulated Treg cells.