Immunologic response at week 24 as a function of tropism status (N = 325).

1Median CD4+ T-cell count at week 24 and change from baseline and inter-quartile range are shown. For subjects who did not complete 24 weeks of the MOTIVATE or A4001029 trial, the last observation is carried forward.2TF-ES: Trofile Enhanced Sensitivity (Monogram Biosciences); Reflex Test: triplicate population sequencing (TPS) with reflex of specimens with an R5 result to ultradeep sequencing (UDS). TPS g2p5.75 and g2p10: TPS with geno2pheno FPR cutoffs of 5.75% and 10% respectively. TPS (pssm): position specific scoring matrix for X4R5 with a cutoff of −4.75. TPS (g+p): predictions based on combined g2p5.75 and PSSMx4r5.3P-values were determined using a two-sided Wilcoxon test.