首页/数据集/Dexamethasone treatment alters levels of insulin, leptin, and adiponectin but does not have metabolic effects across generations

Dexamethasone treatment alters levels of insulin, leptin, and adiponectin but does not have metabolic effects across generations

ChEBI2015-11-25 更新2026-07-12 收录

糖皮质激素代谢效应

跨代内分泌表型

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-67290 数据链接链接失效反馈

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资源简介：

Dexamethasone treatment alters levels of insulin, leptin, and adiponectin but does not have metabolic effects across generations

应用场景：

创建时间：

2015-11-25

糖皮质激素代谢效应

组织基因表达

Context: Glucocorticoids are frequently prescribed drugs with important side-effects such as glucose intolerance and tissue remodelling. Objective: The goal was to explore the molecular basis of the

NIAID Data Ecosystem70

Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men. Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men

糖皮质激素代谢效应

棕色脂肪组织活性

Glucocorticoids (GCs) are widely applied anti-inflammatory drugs that are associated with adverse metabolic effects including insulin resistance and weight gain. Previous research indicated that GCs m

NIAID Data Ecosystem20

Ehmt2's transcriptional coactivation restricts glucocorticoid-induced insulin resistance in a study with male mice

胰岛素抵抗

糖皮质激素代谢效应

Glucocorticoids play a key role in metabolic adaptation during stress, such as fasting and starvation. Excess and/or chronic glucocorticoid exposure, however, causes metabolic disorders that include i

NIAID Data Ecosystem00

Dexamethasone treatment alters levels of insulin, leptin, and adiponectin but does not have metabolic effects across generations. Mus musculus

糖皮质激素代谢效应

跨代表观遗传

Genome-wide expression analysis of sperms did not identify significant transcriptome changes upon dexamethasone treatment in mice. These results are consistent with the observation that dexamethasone

NIAID Data Ecosystem20

Dex treatemnt decreases body and muscle weight in mice.

糖皮质激素代谢效应

小鼠生理指标

12 week-old male mice (C57/BL6) were injected with Dex (5 mg/kg twice a day) for 14 days, n = 5 mice in each groups.

Figshare2015-12-02 更新10