Precomputed PharmGScore Variant Deleteriousness Scores for Pharmacogenomic Analysis

# README: PharmGScore Dataset **Title**: Precomputed PharmGScore Variant Deleteriousness Scores for Pharmacogenomic Analysis **Associated Manuscript**: "Computational variant predictors for pharmacogenomics: from evaluation of single alleles to assessment of adverse drug reactions to antidepressants"_ --- ## Description This dataset provides **precomputed PharmGScore values** for all possible single-nucleotide variants (SNVs) located in human protein-coding exons ±60 base pairs, across selected pharmacogenes. PharmGScore is a pharmacogenomics-specific variant scoring metric developed by aggregating multiple general-purpose predictors, designed to capture the potential functional impact of both known and novel variants in pharmacogenes. These scores can be used to evaluate variant deleteriousness in sequencing studies (e.g., WES) and are intended as a scalable alternative or complement to star allele classification in pharmacogenomics. --- ## PharmGScore Calculation Summary PharmGScore is an **ensemble score** derived from the following tools:- CADD- FATHMM-XF- MutationAssessor- PROVEAN