Daily lung expression data from young and old mice

Circadian rhythms control the diurnal nature of many physiological, metabolic and immune processes. Circadian rhythms are tightly controlled by positive and negative transcriptional loops; This circuitry is altered during aging altering tissue daily function. Lungs from 2-month-old and 22-month-old male mice were perfused with PBS and harvested every 4 hours from ZT0 (Light on) to ZT24 with ZT12 corresponding to light off.昼夜节律（Circadian Rhythm）调控众多生理、代谢与免疫过程的昼夜节律性。昼夜节律由正、负转录环路严格调控；该调控网络在衰老过程中发生改变，进而影响组织的日常生理功能。本研究对2月龄与22月龄雄性小鼠的肺部采用磷酸盐缓冲液（Phosphate Buffered Saline, PBS）灌流，并于节律时间（Zeitgeber Time, ZT）0（光照开启）至ZT24期间每4小时采集一次肺部样本，其中ZT12对应光照关闭时刻。