Summary of the metabolites found to be significantly varied in either analytical platform after 30 months low-dose Pio-Flu-Met polytherapy.

d = doublet, s = singlet, m = multiplet. Percentage of variation was calculated for each patient as the area of the spectral region or selected XCMS feature at baseline minus the area of the same feature or spectral region after the treatment relative to the former. Values are expressed as mean ± SEM. A negative value indicates that levels of the corresponding metabolite resulted significantly decreased with the treatment while positive values indicate a significant increase. p-values correspond to Wilcoxon rank-summed test and FDR correction. Statistical significance was considered for those spectral regions or features having p-corrected values2;§Indicates those metabolites whose retention time and mass spectra were checked using pure standard references.