Fibrosis.

Fibrosis scoring: α-SMA (hepatic stellate cell activation) and reticulin grading (collagen type III) in five COMMD1-deficient dogs in a time-dependent copper-induced hepatitis. Data are presented as median (range).
α-SMA grading; 0: no staining of HSCs; 1: a few positive HSCs; 2: diffuse staining of HSCs; 3: mild increased staining of HSCs; 4: marked increased staining of HSC and compared with age matches normal controls.
Reticulin grading; grade 0: normal, grade 1: local mild centrilobular increase, grade 2: multifocal mild to moderate centrilobular increase, grade 3: moderate increase with centro-central bridging or nodular transformation. The uncorrected p-values for comparison of each time point with 6 months of age are reported in the table. No significant differences are present when correcting these p-values for the number of tests.