Associations between IgG antibody responses and CHMI outcome measures.

Associations are reported between anti-MSP119 or anti-AMA1 total IgG ELISA titer readouts at various time-points and/or fold-change post-CHMI (as in Figure 1E), as well as with time to malaria diagnosis by thick-film microscopy during CHMI, and parasitemia at time of diagnosis (measured by qPCR in terms of parasites/mL blood). In all cases, Spearman’s rank correlation coefficient and P value are shown. n/a = not applicable; n.d. = not done. *For these analyses, relevant vaccine groups were included: for the MSP119 analysis, data were combined from the MSP1-only vaccination group and from the MSP1+AMA1 and MSP1+ME-TRAP co-administration groups; and for the AMA1 analysis data were combined from the AMA1-only vaccination group and from the MSP1+AMA1 co-administration group.Associations between IgG antibody responses and CHMI outcome measures.