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Tandem Radical Fluoroalkylation–Cyclization: Synthesis of Tetrafluoro Imidazopyridines

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https://figshare.com/articles/dataset/Tandem_Radical_Fluoroalkylation_Cyclization_Synthesis_of_Tetrafluoro_Imidazopyridines/2080762
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A copper-catalyzed fluoroalkylation–cyclization sequence of alkenes and alkynes enables the synthesis of fluorinated tetra- and dihydro­imidazo­pyridines in moderate to excellent yields within 1 h at 70 °C. This reaction, which is carried out using copper­(I) acetate as the catalyst, makes use of a new class of functionalized tetrafluoroethyl reagents based on a hypervalent iodine scaffold.
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2016-02-12
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