Additional file 2 of Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome

Additional file 2: List of the 880 significant differentially methylated CpG sites obtained by the RnBeads Differential Methylation analysis. Annotation of Illumina positions was obtained using wANNOVAR. The different columns are explained as: Illumina_TargetID: site id; Chr: chromosome of the site; Start: start coordinate of the site; End: end coordinate of the site; mean.diff: difference in methylation means between the two groups: mean.g1(mild)-mean.g2(severe); diffmeth.p.val: p-value obtained from linear models employed in the limma package; diffmeth.p.adj.fdr: FDR adjusted p-value of all sites, Epimutation_Type: classification of the differentially methylated site; Func.refGene: CpG site classification according to the position of the annotated gene; Gene.refGene: Gene name associated with the differentially methylated site; GeneDetail.refGene: relative distance(s) from nearest gene(s); 21_CpG_SIGNATURE: CpG univocally associated to Group 4.