Analysis code and supporting data for GFRAL signal comparisons in hyperemesis gravidarum
收藏资源简介:
This archive provides analysis code and author-generated supporting data for component-specific molecular comparisons across six hyperemesis gravidarum loci, with detailed GFRAL analyses. It includes complete reported molecular estimates, signal-level posteriors, convergence and reference-LD diagnostics, matched-variant single-causal and multi-signal comparisons, and instructions for selected reproducible calculations. The primary rs12210212 component is distinguished from the secondary rs9370418 region and CSF measurements. Conventional multi-signal support remains model dependent; all associated non-supporting and uncertain results are retained. Version 1.0.1 updates figure-rendering code and source tables to display all seven eligible MR tests, clarifies the distinction between matched variant-level coloc priors and model-specific effect-size priors, and makes unresolved tissue-specific evidence explicit. The fifteen Data S CSV tables and previously reported numerical estimates are unchanged. No manuscript, publication figures, formatted supplementary workbooks, individual-level genotypes, access credentials or restricted provider datasets are included. Author-generated code is under the MIT License; derived data and documentation are under CC BY 4.0. Third-party source data remain subject to provider terms. Full upstream analyses require separately obtained provider inputs, as documented in REPRODUCE.md.



