Response to DNA Damage

The Response to DNA Damage network depicts the causal mechanisms that are involved in multiple DNA damage response pathways. This includes those components that regulate TP53, TP63, and TP73 activities, the impact of G1/S and G2/M transitions of the cell cycle downstream of DNA damage, and DNA repair processes following single-strand and double-strand DNA damage. The network describes inhibition of DNA repair by various exogenous compounds, as well as components that function in nucleotide excision repair such as the XP proteins.\u003c/p\u003e\n\u003ch2\u003eJamboree Review Focus\u003c/h2\u003e\n\u003cp\u003eInterplay of components medaiting the processes of non-homologous end-joining (NHEJ) and homologous recombination (HR). Reviewed during Jamboree2014