Epigenetic marks imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma (MCC)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178155
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Differences in DNA-methylation between VP- and UV-MCCs mainly refer to heterogeneity in carcinogenesis rather than an origin in utterly different cell types. Indeed, a principal component derived scoring suggest an epithelial for UV-MCC as well as VP-MCC cell lines. This study compared the DNA methylation patterns of virus- (VP-MCC) and UV-light associated (UV-MCC) Merkel cell carcinoma cell lines
创建时间：
2022-03-04
