H6pd
收藏rgd.mcw.edu2025-03-23 收录
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1623867
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资源简介：
Enables 6-phosphogluconolactonase activity and glucose-6-phosphate dehydrogenase activity. Involved in regulation of cortisol biosynthetic process. Acts upstream of or within pentose-phosphate shunt. Is active in sarcoplasmic reticulum. Is expressed in alimentary system; cerebral cortex; cranium; heart; and liver. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
激活6-磷酸葡萄糖内酯酶活性和葡萄糖-6-磷酸脱氢酶活性，参与皮质醇生物合成过程的调节。在磷酸戊糖途径的上游或途径中发挥作用。在肌浆网中呈现活性。表达于消化系统、大脑皮层、颅骨、心脏和肝脏。该基因的人类同源基因与皮质酮还原酶缺乏症、皮质酮还原酶缺乏症1和多发性硬化症有关。与人类的H6PD（己糖-6-磷酸脱氢酶/葡萄糖-1-脱氢酶）同源。[由基因组资源联盟提供，2024年11月]
提供机构：
Rat Genome Database
