CDKN2B promotes the metastasis of colorectal cancer cells and 5-fluorouracil resistance by negatively regulating MTAP

The sensitivity of colorectal cancer cells to drugs is significantly low, which requires higher drug concentrations to realize the intended therapeutic outcomes. To address this clinical issue, the present study explored the critical genes linked to drug resistance and their functional pathways related to the widely utilized drug, 5-fluorouracil (5-FU), in colorectal cancer.