The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 and the kinetics of blood lactate production and removal after high-intensity efforts in elite males: a cross-sectional study

This cross-sectional study investigated the effect of genetic variations in monocarboxylate transporter (MCT) genes on lactate production and removal in 337 male athletes from Poland and the Czech Republic. Participants underwent high-intensity intermittent Wingate tests, with DNA samples collected for SNP analysis. Results showed that the MCT2 TAC haplotype was more prevalent in sprinters, correlating with increased lactate concentration differences and altered lactate clearance. The study highlights potential genetic biomarkers for sprinting performance while emphasizing the need for further research to explore underlying mechanisms and the complex influences on athletic performance.