Change from baseline in psychiatric symptoms scores with varenicline or placebo.

Each value represents mean ± s.e.m. of model estimated difference score (wki-baseline). SANS Modified Total = Sum of scores of Affective Flattering, Alogia, Avolition, Anhedonia. PANSS Depression is sum of scores from items G2+G3+G6 (adopted from Lancon [58]. F represents results of analysis of covariance, with baseline scores as covariate. PANSS and Calgary Depression scores used SAS Mixed Model with difference scores from week 4 and week 8 and baseline score as covariate. SANS was analyzed by SPSS Univariate ANCOVA GLM of week 8-baseline difference score with baseline score as covariate. Statistical significance of mean difference from 0 (i.e., no change) for measure for each drug group at specific time point: