Bulk RNA-seq analysis of AvCreERT2;Piezo2fl/fl and control mouse trigeminal ganglion at PN6.5
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资源简介：
Piezo2+ sensory neurons, which are responsible for mechanosensation, regulate tooth root formation by controlling the secretion of PDGF (platelet-derived growth factor) ligands through the PIEZO2 mechanosensory ion channel. Furthermore, loss of Piezo2 in sensory nerves disrupts nerve-derived PDGFA secretion, impairing the regulation of progenitor fate by PDGF signaling in the dental mesenchyme and resulting in defective tooth root development.
创建时间：
2025-01-11
