Hazard Ratios (and 95% CIs) for Death per Standard Deviation of FGF23 and Klotho levels and according to the level tertiles.

*Model 1 = demographics: adjusted for age, gender (male) and by dialysis center clustering.†Model 2 = dialysis specific risk factors and comorbid conditions: adjusted for covariates in Model 1 plus dialysis vintage, systolic and diastolic blood pressure, body-mass index, vascular access on study enrolment (fistula, graft, catheter), coexisting conditions listed in Table 1 (coronary artery disease, valvular heart disease, atrial fibrillation, pulmonary hypertension, implantable cardioverter defibrillator carrier; diabetes mellitus, peripheral vascular disease, stroke, vasculitis, malignoma, chronic obstructive pulmonary disease), cause of renal failure (diabetic nephropathy, hypertensive nephropathy, glomerulonephritis, polycystic kidney disease, others/unknown), medication use listed in Table 1 (phosphate binders, vitamin D replacement, angiotensin converting enzyme inhibitors or angiotensin receptor blockers, beta blockers, aspirin, anticoagulant or clopidogrel, statin), pooled Kt/V.‡Model 3 = fully adjusted model: adjusted for covariates in Model 2 plus parathyroid hormone, 25(OH)vitamin D, phosphate, calcium, albumin, hemoglobin, C-reactive protein, cholesterol.§Patients were categorized according to Klotho level tertiles at enrolment (1st tertile nd tertile 286–392 pg/ml, 3rd tertile >392 pg/ml).||Patients were categorized according to FGF23 level tertiles at enrolment (1st tertile nd tertile 118–468 RU/ml, 3rd tertile >468 RU/ml).Abbreviations: FGF23, fibroblast growth factor 23; HR, hazard ratio; R, reference.