Supplementary materials: Review and estimation of disutility for joint health states of severe and non-severe hypoglycemic events in diabetes

These are peer-reviewed supplementary materials for the article 'Review and estimation of disutility for joint health states of severe and nonsevere hypoglycemic events in diabetes' published in the Journal of Comparative Effectiveness Research.Supplementary Material 1: Literature Search StrategiesSupplementary Material 2: Methods of estimating disutility of the joint four health states: daytime NSHE, nocturnal NSHE, daytime SHE, and nocturnal SHESupplementary Material 3: Estimation of Disutility for Joint Two Health States of SHEs and NSHEsSupplementary Material 4: Disutility Data for Construct ValiditySupplementary Material 5: Details of Studies Included in Literature ReviewSummary: Aim: Many economic evaluations used linear or log-transformed additive methods to estimate the disutility of hypoglycemic events in diabetes, both nonsevere (NSHEs) and severe (SHEs). Methods: We conducted a literature search for studies of disutility for hypoglycemia. We used additive, minimum and multiplicative methods, and the adjusted decrement estimator to estimate the disutilities of joint health states with both NSHEs and SHEs in six scenarios. Results: Twenty-four studies reported disutilities for hypoglycemia in diabetes. Based on construct validity, the adjusted decrement estimator method likely provides less biased estimates, predicting that when SHEs occur, the additional impact from NSHEs is marginal. Conclusion: Our proposed new method provides a different perspective on the estimation of quality-adjusted life-years in economic evaluations of hypoglycemic treatments.

本数据集为发表于《比较疗效研究杂志》的论文《对糖尿病中严重和非严重低血糖事件联合健康状况的不适度的回顾与评估》的同行评审补充材料。补充材料1：文献检索策略；补充材料2：评估联合四种健康状况（日间非严重低血糖事件、夜间非严重低血糖事件、日间严重低血糖事件和夜间严重低血糖事件）不适度的方法；补充材料3：评估严重低血糖事件和非严重低血糖事件联合两种健康状况的不适度；补充材料4：构建效度验证的不适度数据；补充材料5：文献综述中包括的研究详情。摘要：目的：众多经济评估采用线性或对数转换的加性方法来评估糖尿病中非严重（NSHEs）和严重（SHEs）低血糖事件的不适度。方法：我们对低血糖不适度的研究进行了文献检索。我们采用了加性、最小和乘性方法，以及调整递减估计器来估计六种场景下非严重低血糖事件和严重低血糖事件联合健康状况的不适度。结果：有24项研究报告了糖尿病中低血糖的不适度。基于构建效度，调整递减估计器方法可能提供了较少偏差的估计，预测当严重低血糖事件发生时，非严重低血糖事件的额外影响微乎其微。结论：我们提出的新的方法为低血糖治疗的经济评估中质量调整生命年的评估提供了不同的视角。