Gene expression in adult sciatic nerves upon miRNA ablation and crush injury

We report RNA sequencing data from induced Schwann cell specific knockouts for DICER and DGCR8 as well as crush injured wild type animals. Induced deletion of DICER and DGCR8 results in expression of numerous injury response genes suggesting a requirement of those proteins in maintaining the myelinated Schwann cell fate. Overall design: Sciatic nerve RNA expression profiles of adult 3 months post tamoxifen induced P0-CreERT2-Dicer and P0-CreERT2-Dgcr8 mice (in triplicate) and C57BL6 3 days post crush injury (in quadruplicate) in comparison to contralateral (in quadruplicate) and uncrushed controls (in triplicate) were generated by deep sequencing, using Illumina HiSeq.