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yH2AX ChIP sequencing of young and senescent MRC-5 cells

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NIAID Data Ecosystem2026-03-12 收录
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Replicative senescence is characterized by telomere shortening and DNA damage response activation at telomeres. Here we set to establish the genome-wide activation of DNA damage response by doing native ChIP sequencing of the gamma H2A.X (phospho S139) protein in young (population doubling 26) and fully senescent MRC-5 primary fibroblast cells (population doubling 67).

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2020-11-05
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