Data from: Neuregulin-1β augments adaptive concentric remodeling and systolic function without exacerbating hypertrophy during pressure-overload

The study compares three groups of mice one week after pressure overload
induced by transverse aortic constriction (TAC) or control (sham) surgery.
Comprehensive echocardiographic datasets are provided in supplementary
tables, including male mice assessed at 1 week (Table S1) and up to 4
weeks (Table S2) after surgery, as well as female mice assessed at 1 week
(Table S3). The accompanying XLSX file contains complete lists of
differentially expressed genes identified through bioinformatic analysis
of the RNA-sequencing data. Supplementary Figure S1 presents volcano plots
and pathway analyses of genes differentially expressed among experimental
groups. Supplementary Figure S2 highlights 23 genes that were
differentially expressed both between neuregulin-1β (NRG1)–treated TAC
mice and saline-treated TAC controls, and between NRG1-treated TAC mice
and sham controls. Supplementary Figure S3 reports results from an
additional experiment using intermittent NRG1 administration via daily
intraperitoneal injections, complementing the continuous delivery approach
used in the main study. Supplementary Tables S4 and S5 detail the
antibodies and primer sequences used. Together, these data support
analyses of gene expression and NRG1-treatment effects in experimental
models of pressure overload.