Transcriptomic analysis after proton and neutron therapy

Study of molecular signatures in three types of objects after proton (human) and neutron (cell model, xenograft) irradiation Overall design: The aim of the study was to establish common and distinct molecular signatures activated by particle therapy in three types of objects - patient material (tumor tissue and peritumoral tissue) from patients with head and neck cancer, in a cell line of a human larynx strain in the form of a tumoroid obtained at ultra-low adhesion plastic and in a cell strain of the larynx, implanted subcutaneously in an immunodeficient mouse. Irradiation was carried out at an installation at the Medical Radiological Research Center named after. A.F. Tsyba with a final total dose of 10 Gy.