Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

ChEBI2014-11-24 更新2026-07-21 收录

干细胞重编程

表观遗传记忆

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62150 数据链接链接失效反馈

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Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

创建时间：

2014-11-24

The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]. The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]

干细胞重编程

早期胚胎发育

IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how the cytokine is regulated and if it plays a role during embryo development r

NIAID Data Ecosystem50

Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens

干细胞重编程

转录因子功能

Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu

NIAID Data Ecosystem40

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]

干细胞重编程

染色质可及性调控

Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil

NIAID Data Ecosystem40

Analysis of Differential Proteomes of Induced Pluripotent Stem Cells by Protein-Based Reprogramming of Fibroblasts

干细胞重编程

蛋白质组学比较分析

The recent generation of induced pluripotent stem (iPS) cells represents a novel opportunity to complement embryonic stem (ES) cell-based approaches. iPS cells can be generated by viral transduction o

Figshare2016-02-23 更新50

Epigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [SNP array]

干细胞重编程

神经细胞表观遗传学

Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs)

NIAID Data Ecosystem40

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

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