L1000 dataset for the 9989 chemicals

Dataset extracted from the L1000 mRNA profiling assay (LINCS from the NIH), phase 1 (http://identifiers.org/lincs.data/LDG-1227) and phase 2 (https://doi.org/10.1016/j.cell.2017.10.049) and used for the study "Linking chemicals, genes and morphological perturbations to diseases" (Cerisier et al., 2023, Toxicology and Applied Pharmacology). It contains data on 12328 genes for the 9989 compounds mentioned in the study. It contains 178925 rows; one row corresponds to one experimental condition: one compound tested on one cell type at one dose and one time. The column “hash” represents this condition: “compounds=celltype=dose=time=Inf/Sup”. The Inf/Sup information represents the sign of the z-score, If the z-score is negative and below -2.00, the symbol “Inf” is marked. If it is positive and greater than 2.00, the symbol “Sup” is marked. Z-scores between -2.00 and 2.00 are not taken into account, they do not mean any gene disturbance and they do not appear in the dataset. The "genes" column corresponds to the genes (their EntrezIDs), separated by a comma, that are perturbed by the corresponding condition in the "hash" column. The “inchikey” column is basically the inchikey of the molecules concerned by the "hash" column and the “BROAD_ID” column corresponds to the molecule ID provided by the Broad Institute.