Second-Generation Synthesis of (-)-Viriditoxin
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下载链接：
http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1289651
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资源简介：
Viriditoxin is a secondary metabolite isolated from Aspergillus viridinutans that
has been shown to inhibit FtsZ, the bacterial homologue of eukaryotic
tubulin. A streamlined, scalable, and highly diastereoselective
synthesis of this complex natural product is described. Key advances
include a more efficient synthesis of the requisite unsaturated
pyranone, scalable assembly of the naphthopyranone monomer, and
improved diastereoselectivity in the biaryl-coupling reaction. In
addition, we disclose a serendipitous ruthenium-catalyzed anion
dimerization resulting from trace metal left by an RCM reaction.
提供机构：
Georg Thieme Verlag, Stuttgart, New York
创建时间：
2012-01-26
