Recurrent glioblastoma (GBM) has a grim prognosis, though MGMT promoter methylation and IDH mutation provide a significant survival advantage. The product of IDH mutation, 2-hydroxyglutarate, increas

NIAID Data Ecosystem60

Identification of novel molecular subgroups in esophageal adenocarcinoma to predict response to neo-adjuvant therapies

肿瘤分子分型

治疗反应预测

Esophageal adenocarcinoma (EAC) is a highly aggressive cancer and its response to chemo-, and radiotherapy is unpredictable. EAC are highly heterogeneous at the molecular level. The aim of this study

NIAID Data Ecosystem50

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin [expression]

母细胞瘤表观遗传学

干细胞自我更新

Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of functional prop

NIAID Data Ecosystem60

Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma

肿瘤分子分型

精准肿瘤学

Oncogenic KRAS mutations are absent in approximately 10% of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with therapeutic options beyond stan

NIAID Data Ecosystem60

Stability of the CpG island methylator phenotype during glioblastoma progression.

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