Click Chemistry Inspired Synthesis of Morpholine-Fused Triazoles

The
synthesis of triazolyl azido alcohols from terminal alkyne
via oxirane ring-opening of epichlorohydrin, followed by click reaction
with alkynes, and subsequent azidation of chlorohydroxy triazoles
was achieved under a one-pot methodology. The developed triazolyl
azido alcohols were further utilized for the synthesis of a diverse
range of morpholine-fused triazoles of chemotherapeutic value. The
structure of all developed compounds has been elucidated using IR,
NMR, MS, and elemental analysis, where four of them have been characterized
by single-crystal X-ray analysis.