miR-378 binds RUNX1 mRNA

The mature microRNA miR-378a-3p, one of the two single strand products derived from microRNA miR-378 encoded by the MIR378 gene locus, binds the 3'UTR of the RUNX1 mRNA. Since miR-378 does not induce RUNX1 mRNA degradation, it is assumed that miR-378 functions as a component of the nonendonucleolytic RISC. Levels of miR-378 are decreased in triple negative breast cancer (Browne et al. 2016).

成熟的微小RNA miR-378a-3p，为MIR378基因座编码的微小RNA miR-378产生的两个单链产物之一，与RUNX1信使RNA的3'非翻译区（3'UTR）相结合。鉴于miR-378不会诱导RUNX1信使RNA的降解，因此推测miR-378作为非内切核酸酶性RNA诱导沉默复合物（RISC）的组成部分发挥作用。在 Triple Negative Breast Cancer（TNBC，三阴性乳腺癌）中，miR-378的水平降低（Browne et al. 2016）。