Summary of RNAi screen results.

Within our large-scale RNAi screen, a single gene is often targeted by multiple shRNA constructs. Columns H and I depict the number of constructs and corresponding nucleotide sequences, respectively. Gene symbols of the shRNA targets are given in column A. Target oscillatory properties of Bmal1-luciferase expression are estimated using the ChronoStar software; see Materials and methods. Using the RSA method, we statistically access whether an oscillatory property such as the amplitude, damping rate, or period significantly deviates from the norm in one or the other direction, i.e., 2 P values per parameter are given. Columns B-G depict decadic logarithms of the corresponding P values. (XLS)