不同预后群体的临床肺癌组织临界状态蛋白质组、磷酸化蛋白质组数据集

肺鳞癌患者术后早期复发是影响患者术后生存的主要障碍。但肺鳞癌术后早期复发的分子机制尚不清楚，同时也缺乏有效预测早期复发的生物标志物。在肺鳞癌术后早期复发的分子机制及生物标志物研究方面，我们应用了定量蛋白质组学方法分析了20名肺鳞癌患者的原发肿瘤样本，鉴定到了131个在早期复发（癌症复发时间小于10个月）与晚期复发（癌症复发时间大于30个月）的患者中差异表达的蛋白质。Early postoperative recurrence of patients with lung squamous cell carcinoma is a major obstacle affecting their postoperative survival. However, the molecular mechanisms underlying early postoperative recurrence of lung squamous cell carcinoma remain unclear, and effective biomarkers for predicting early recurrence are also lacking. In our study on the molecular mechanisms and biomarkers of early postoperative recurrence of lung squamous cell carcinoma, we applied quantitative proteomics to analyze primary tumor samples from 20 patients with lung squamous cell carcinoma, and identified 131 differentially expressed proteins between patients with early recurrence (cancer recurrence time < 10 months) and those with late recurrence (cancer recurrence time > 30 months).

搜集汇总

背景与挑战

背景概述

该数据集基于定量蛋白质组学方法，分析了20名肺鳞癌患者的原发肿瘤样本，旨在探究术后早期复发的分子机制并寻找相关生物标志物。研究鉴定了131个在早期复发（小于10个月）与晚期复发（大于30个月）患者中差异表达的蛋白质。