The percentages of AUC of bone volume and MM-cell density when positive feedback cycles are blocked to those when these cycles are intact.

Note: case 1: Positive feedback cycle A is blocked at regulation mechanism between IL-6 and osteoblast precursors; case 2: Positive feedback cycle B is blocked at regulation mechanism between IL-6 and MM cells; case 3: Positive feedback cycle A and B are simultaneously blocked at regulation mechanism of IL-6 production; Case 4: additional pathway to positive feedback cycle A is blocked at regulation mechanism of OPG degradation by MM cells. Case5: additional pathway to positive feedback cycle B is blocked at regulation mechanism of MM-BMSC adhesion-stimulated MM-cell proliferation.