Description of the most frequent nonsynonymous (nsSNPs) polymorphisms used to construct DBPII haplotypes, their frequencies in each geographic population and presence in described epitopes.

a: Amino acid numbers according to SAL-1 sequence [39] with the first letter representing the amino acid present in Sal-1 sequence and the latter representing the polymorphism;b: H1, H3, M2 and M3 are B-cell epitopes [51]; 5 – T and B-cell epitope; 45 and 48 are B-cell epitopes; 66 – T-cell epitope [52], [53]; Ia and Id – MHC class I in silico predicted promiscuous epitopes [35]; 1638 – MHC class II universal epitope [54];*- polymorphisms that alter the antigenic character of DBPII[32].