Additional file 1 of Uncovering the protective mechanism of Taohong Siwu decoction against diabetic retinopathy via HIF-1 signaling pathway based on network analysis and experimental validation

Additional file 1: Table S1. Sixty one active ingredients found in Taohong Siwu decoction (THSWD) after overlapped ingredients were subtracted. The active ingredients were obtained from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database ( http://lsp.nwu.edu.cn/tcmsp.php ) according to meeting the criteria of oral bioavailability (OB ≥ 30%) and drug-likeness (DL ≥ 0.18). Table S2. Two thousand three hundred forty targets of active ingredients of THSWD. The targets were identified using ChemMapper database ( http://lilab.ecust.edu.cn/chemmapper/ ) according to the criteria of 3D structure similarity above 0.85 and prediction score above 0 and PharmMapper ( http://lilab.ecust.edu.cn/pharmmapper/index.php ) databases according to the target pharmacophore approach. Table S3. Two hundred sixty three diabetic retinopathy (DR)-associated genes. DR-associated genes were searched from DisGeNET database ( http://www.disgenet.org/web/DisGeNET/menu/home ), DrugBank database ( https://www.drugbank.ca/ ), and Therapeutic Target Database (TTD) ( https://db.idrblab.org/ttd/ ). Table S4. Characterization of chemical constituents of THSWD by UPLC–ESI-Q-TOF/MS.