Circadian oscillations and their LAN-induced disruption in tumor cAMP signaling, fatty acid uptake and metabolism, the Warburg effect and proliferative activity and their impact on tumor growth.

*Robustness is the percent of variance explained by the fitted cosine model. **Total fatty acid uptake cosinor analysis recapitulated linoleic acid uptake results (data not shown). †P-Values are for cosinor analysis performed on raw individual data with a fixed 24-hr period; n = 36 for LD,12∶12 and n = 36 for LAN for each analyte.