Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ
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https://figshare.com/articles/dataset/Discovery_of_Highly_Isoform_Selective_Thiazolopiperidine_Inhibitors_of_Phosphoinositide_3_Kinase_/2147008
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资源简介：
A series of high affinity second-generation
thiazolopiperidine
inhibitors of PI3Kγ were designed based on some general observations
around lipid kinase structure. Optimization of the alkylimidazole
group led to inhibitors with higher levels of PI3Kγ selectivity.
Additional insights into PI3K isoform selectivity related to sequence
differences in a known distal hydrophobic pocket are also described.
创建时间：
2016-02-13
