mARC's physiological function in the biotransformation of xenobiotics - especially in lipid metabolism and non-alcoholic fatty liver disease (NAFLD) using several models

Background: Recent studies reveal an association between the mitochondrial Amidoxime Reducing Component (MTARC) 1 and 2 proteins and metabolism in Mtarc1/2-deficient mice that are resistance to diet-induced obesity; however, the impact of Mtarc1/2 knockout (KO) on the gut microbiota and metabolome has not been explored in the context of sex and diet.Aim: To compare the effects of a Western diet (WD) or a Novel Gubra Amylin NASH (GAN) diet on body weight gain, and on the composition of the gut microbiome and metabolome, between the background mouse strain and male and female Mtarc1- or Mtarc2-KO mice.