TfOH-Catalyzed Cascade C–H Activation/Lactonization of Phenols with α‑Aryl-α-diazoesters: Rapid Access to α‑Aryl Benzofuranones
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下载链接：
https://figshare.com/articles/dataset/TfOH-Catalyzed_Cascade_C_H_Activation_Lactonization_of_Phenols_with_Aryl-_-diazoesters_Rapid_Access_to_Aryl_Benzofuranones/13033354
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资源简介：
Aryl benzofuranones
are privileged structural units present in natural products and pharmaceutically
relevant compounds with high bioactivity and therapeutic value; synthetic
access to these scaffolds remains an area of intensive interest. A
new and efficient TfOH-catalyzed cascade ortho C–H
activation/lactonization of phenols with α-aryl-α-diazoacetates
is reported. This metal-free protocol provides an operationally simple
and rapid method for the one-pot assembly of diverse α-aryl
benzofuranones in high yields with broad substrate scope, a readily
starting material, good chemo-regioselectivity, and excellent functional
group compatibility.
创建时间：
2020-09-22
