Dephosphorylation of inactive SRC by PTPB1

The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity.

整合素αIIbβ3：非活性SRC复合物招募PTP1B蛋白酪氨酸磷酸酶，从而导致SRC酪氨酸530位的去磷酸化。磷酸化的SRC尾部与SH2结构域相互作用，从而抑制激酶活性；磷酸化去除激活SRC激酶活性。