Destabilization/reconsolidation process and hippocampal spine remodeling-Comas Mutis et al 2021

In the present work we studied the interaction between two key neural structures involved in the reconsolidation process: the basolateral complex of the amygdala (BLA) and the dorsal hippocampus (DH). Our results show changes in the structural plasticity of the CA1 region of the DH in the form of dendritic spines density changes associated with the destabilization/reconsolidation process. Furthermore, we demonstrate a modulatory role of BLA over said plasticity infusing different drugs such as ifenprodil, a destabilization blocker, and propranolol, a reconsolidation disruptor, in this structure. Altogether our work shows a particular temporal dynamic in the CA1 region of DH that accompanies the destabilization/reconsolidation process and aims to provide new information on the underlying mechanisms of this process that may help create a better understanding of memory storage, maintenance, expression and updating and its potential medical applications.