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Crystal structure of human Sirt2 in complex with a 1,2,4-oxadiazole based inhibitor

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Protein Data Bank Japan2024-07-10 更新2026-04-19 收录
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Crystal structure of human Sirt2 in complex with a 1,2,4-oxadiazole based inhibitor Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-chloranyl-~{N}-[4-[5-[[(3~{S})-1-[(3-fluoranyl-2-methyl-phenyl)methyl]piperidin-3-yl]methyl]-1,2,4-oxadiazol-3-yl]phenyl]benzamide, ... Authors: Friedrich, F, Colcerasa, A, Einsle, O, Jung, M. Deposit date: 2023-07-24 Release date: 2024-06-19 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. J.Med.Chem., 67, 2024
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2023-07-24
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