Protective efficacy against clinical malaria by month after IPTi.

Estimates of protective efficacy against clinical malaria, calculated as (1- rate ratio of active treatment [SP, CD or MQ] vs. placebo). All regression models were adjusted for the covariates ITN use, rural residence and distance from nearest health facility. Mefloquine (All IPT rounds) was also adjusted for IPT round. Most children exited follow-up after the administration of IPT1 around one month later, when they received IPT2 at approximately 3 months of age. For this reason this analysis was not possible for follow-up after IPT1. Abbreviations: CI, confidence interval; SP, sulfadoxine-pyrimethamine; CD, chlorproguanil-dapsone; MQ, mefloquine.