The list of the most significant SNPs (FDR<25%) associated with plasma HIV-RNA levels during primary HIV-1 infection.
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https://figshare.com/articles/dataset/_The_list_of_the_most_significant_SNPs_FDR_lt_25_associated_with_plasma_HIV_RNA_levels_during_primary_HIV_1_infection_/583425
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The following information is given for each SNP: SNP is the rs number; Chr is the chromosome; Position is the position along the chromosome (Human Genome NCBI Build 35.1); PRIMO Q-values are the Q-values for the genome-wide association study with HIV-RNA in the Primo cohort; PRIMO P-values are the P-values for the genome-wide association study with HIV-RNA in the Primo cohort; Beta is the slope parameter (allele indicated in bracket is used as a reference group); CHAVI P-values are the P-values obtained from the CHAVI study; CHAVI rank is the rank of the p-values (obtained from the CHAVI study) according to the Illumina 317K whole-genome single-nucleotide polymorphism arrays. The rank assigned to tied values is calculated by taking the mean of the ranks. MA is the minor allele in the HapMap CEU population; P-values are the P-values for the comparison of allele frequencies between the PRIMO and HIV controllers patients (HIC). The four major SNPs (printed in bold) are those being significantly associated with plasma HIV-RNA and showing enrichment in HIV-controllers for protective allelic variants.
*NA = Not Available (SNP discarded in the Chavi study).
创建时间:
2008-12-24



