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Stereoselective Synthesis of Functionalized Tetrahydro‑1H‑1,2-diazepines by N‑Heterocyclic Carbene-Catalyzed [3 + 4] Annulation

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Figshare2017-09-26 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Stereoselective_Synthesis_of_Functionalized_Tetrahydro_1_i_H_i_1_2-diazepines_by_i_N_i_Heterocyclic_Carbene-Catalyzed_3_4_Annulation/5445136
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资源简介:
An efficient N-heterocyclic carbene (NHC)-catalyzed asymmetric [3 + 4] annulation reaction of N-Ts hydrazones with 2-bromoenals has been developed. A series of functionalized tetrahydro-1H-1,2-diazepines with two consecutive stereocenters was obtained using NHCs as the catalyst in good yields with excellent diastereo- and enantioselectivities.
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2017-09-26
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