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Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer

ChEBI2016-03-01 更新2026-07-12 收录

CDK8抑制剂

结肠基因表达

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-77987 数据链接链接失效反馈

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资源简介：

Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer

应用场景：

创建时间：

2016-03-01

胰岛素信号通路

结肠基因表达

Compared mRNA expression between control and insulin treated cells. HT29 cells were treated with 100nM Insulin for 24h. The RT2 Profiler PCR Arrays PAHS-30C (SA Biosciences, MD, USA) was designed to a

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The effect of deletion of muscarinic acetylcholine receptor 4 in Math1 expressing cells in the small intestine

毒蕈碱受体

结肠基因表达

The muscarinic acetylcholine receptor 4 was inducibly deleted in Math1 expressing lineages and alterations in gene expression evaluated by bulk RNA sequencing Math1Cre*PR mAChR4fl/fl mice and mAChR4fl

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Mouse genes detected by the Quantigene 2.0 Plex RNA Assay in distal colon homogenates of DSS-treated WT and TRPA1 KO mice.

结肠基因表达

TRPA1基因功能

Mouse genes detected by the Quantigene 2.0 Plex RNA Assay in distal colon homogenates of DSS-treated WT and TRPA1 KO mice.

NIAID Data Ecosystem70

Eight published CRC gene expression signatures.

结肠基因表达

生物标志物机器学习验证

LOOCV: Leave One Out Cross Validation; NN: Nearest Neighbor; SVM: Support Vector Machine; TIGR: The Institute for Genomic Research; UMNJ: University of Medicine of New Jersey.

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Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice. Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

肠道微生物群与衰老

结肠基因表达

Diminished colonic health is associated with various age-related pathologies. In this study, we applied an integrative approach to reveal potential interactions between determinants of colonic health

NIAID Data Ecosystem70

Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer

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