Comparing oestrogen-responsive genes in endometrial and breast cancer cell lines. Comparing oestrogen-responsive genes in endometrial and breast cancer cell lines

Up to 80% of endometrial and breast cancers express the oestrogen receptor ERa. Unlike breast cancer, anti-oestrogen therapy has had limited success in endometrial cancer, raising the possibility that oestrogen has different effects in the two cancer types. We investigated the role of oestrogen in endometrial and breast cancers using cell lines and found that oestrogen-responsive genes were predominantly unique between the two cancer types. Overall design: Endometrial and breast cancer cell lines were treated with oestradiol or vehicle for three hours and RNA sequenced in duplicate.